FAM222B

Across TCGA patient cohorts, FAM222B mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM222B-associated genes across cancer lineages are EGFR_pY1068, VHL, and ATM. Each is linked with FAM222B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM222B-to-partner and partner-to-FAM222B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FAM222B-low versus FAM222B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222B→partner) and Y-score (partner→FAM222B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.175	-1.736	.044	.007	3	2
UCEC	VHL →	-0.860	-2.415	<.001	.003	3	2
UCEC	ATM →	-0.360	-2.446	.022	.018	3	2
COAD	Mre11 →	+0.174	+2.815	.007	.036	3	1
COAD	DJ-1 →	+0.202	+2.815	.047	.036	3	1
UCEC	14-3-3_beta →	-0.104	-3.558	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by FAM222B expression — UCEC

Explore this box plot interactively →