FAM222B

Across TCGA cell cohorts, FAM222B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,564 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM222B-associated GO terms across cancer lineages are Regulation of transcription initiation by RNA polymerase II, Epigenetic regulation of gene expression, and Negative regulation of gene expression, epigenetic. Each is linked with FAM222B in more than 13 cancer types. Because this analysis shows association rather than direction, both FAM222B-to-partner and partner-to-FAM222B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription initiation by RNA polymerase II grouped by FAM222B-low versus FAM222B-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222B→partner) and Y-score (partner→FAM222B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of transcription initiation by RNA polymerase II →	+0.065	+0.839	<.001	<.001	3	14
BLOOD_Lymphoma	Epigenetic regulation of gene expression →	+0.050	+0.672	<.001	.001	3	14
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.060	+0.574	.001	<.001	3	14
OESOPHAGUS	Regulation of DNA-templated transcription initiation →	+0.089	+0.964	.002	.007	2	14
BLOOD_Lymphoma	Heterochromatin formation →	+0.057	+0.645	.001	<.001	3	13
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.101	+0.858	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,564 associations by consensus.

Regulation of transcription initiation by RNA polymerase II by FAM222B expression — BLOOD_Lymphoma

Explore this box plot interactively →