FAM222B

Across TCGA cell cohorts, FAM222B mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM222B-associated genes across cancer lineages are OR10T2, TRIM49B, and CDX4. Each is linked with FAM222B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM222B-to-partner and partner-to-FAM222B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by FAM222B-low versus FAM222B-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM222B→partner) and Y-score (partner→FAM222B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10T2 →	+0.091	+3.781	<.001	.009	3	2
BLOOD_Leukemia	TRIM49B →	+0.111	+3.874	<.001	.005	3	2
LARGE_INTESTINE	CDX4 →	+0.011	+3.217	<.001	.006	3	1
LARGE_INTESTINE	OR2T8 →	+0.168	+3.584	<.001	.004	3	1
LARGE_INTESTINE	PPP1R42 →	+0.083	+3.781	.003	.003	3	1
BREAST	OR10K2 →	+0.031	+3.781	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR10T2 by FAM222B expression — BREAST

Explore this box plot interactively →