FAM222A

Across TCGA pan-cancer cohorts, FAM222A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FAM222A data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher FAM222A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM222A expression acts as an unfavorable survival marker.

SKCM, STAD, and ACC are the cancer types where FAM222A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.043	0.731	<.001	23	view →
STAD	OS	Median	III,IV	0.164	0.633	.002	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FAM222A–SKCM (DFS)

Open the SKCM breakdown →