Across TCGA patient cohorts, FAM221A protein abundance is significantly associated with the RNA expression of many other genes, with 3,574 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FAM221A-associated genes across cancer lineages are CRYBG2, STK31, and ANKHD1. Each is linked with FAM221A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM221A-to-partner and partner-to-FAM221A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM221A→partner) and Y-score (partner→FAM221A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CRYBG2 →	+0.806	+0.410	.003	<.001	3	2
GBM	STK31 →	+0.695	+0.555	<.001	<.001	3	2
COAD	ANKHD1 →	+0.312	+0.394	.003	<.001	3	2
LSCC	RHPN2 →	+0.944	+0.427	.002	<.001	3	2
OV	PNISR →	+0.532	+0.466	.004	.004	3	2
GBM	NACAD →	+0.809	+0.460	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,574 associations by consensus.

Exploration

FAM221A survival (RNA) · tumor vs normal (RNA) · all FAM221A data types