Across TCGA patient cohorts, FAM221A mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FAM221A-associated genes across cancer lineages are MIR548AP, HSPA8P6, and SNX9-AS1. Each is linked with FAM221A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM221A-to-partner and partner-to-FAM221A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM221A→partner) and Y-score (partner→FAM221A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548AP →	+0.322	+8.055	<.001	.007	3	2
SKCM	HSPA8P6 →	+0.053	+3.661	<.001	.009	3	1
SKCM	SNX9-AS1 →	+0.305	+4.603	<.001	.001	3	1
SKCM	VN2R9P →	+0.138	+3.913	<.001	.006	3	1
SKCM	RNU6-625P →	+0.388	+4.743	<.001	.005	3	1
SKCM	LINC01743 →	+0.070	+4.656	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Exploration

FAM221A survival (RNA) · tumor vs normal (RNA) · all FAM221A data types