FAM220A

Across TCGA patient cohorts, FAM220A mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM220A-associated genes across cancer lineages are INPP4B, EGFR_pY1068, and Ku80. Each is linked with FAM220A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM220A-to-partner and partner-to-FAM220A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by FAM220A-low versus FAM220A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM220A→partner) and Y-score (partner→FAM220A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.406	-3.459	.005	.005	3	2
UCEC	EGFR_pY1068 →	-0.254	-2.000	.024	.032	3	1
UCEC	Ku80 →	+0.257	+2.013	.015	.018	3	1
UCEC	MEK1 →	+0.582	+3.807	<.001	<.001	3	1
UCEC	Notch1 →	+0.215	+3.807	<.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.512	+2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

INPP4B by FAM220A expression — UCEC

Explore this box plot interactively →