FAM218A

Across TCGA pan-cancer cohorts, FAM218A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FAM218A data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM218A Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM218A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ESCA, and KIRP are the cancer types where FAM218A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	1.000	0.534	.018	22	view →
ESCA	OS	Median	II,III,IV	0.345	0.686	.047	3	view →
KIRP	OS	Median	All	0.248	0.705	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FAM218A–UCEC (DFS)

Open the UCEC breakdown →