Across TCGA patient cohorts, FAM216A mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM216A-associated genes across cancer lineages are FoxM1, TAZ, and Tuberin. Each is linked with FAM216A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM216A-to-partner and partner-to-FAM216A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM216A→partner) and Y-score (partner→FAM216A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.331	+3.321	.014	.010	3	1
UCEC	TAZ →	-0.161	-2.999	.030	.035	3	1
UCEC	Tuberin →	+0.358	+3.009	.011	.019	3	1
UCEC	BRD4 →	+0.420	+2.177	.002	.035	2	1
UCEC	C-Raf →	+0.283	+3.000	<.001	.036	2	1
UCEC	Ku80 →	+0.312	+3.335	.011	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

FAM216A survival (RNA) · tumor vs normal (RNA) · all FAM216A data types