FAM214B

Across TCGA patient cohorts, FAM214B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM214B-associated genes across cancer lineages are C-Raf, STAT5a, and Caspase-7-cleavedD198. Each is linked with FAM214B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM214B-to-partner and partner-to-FAM214B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FAM214B-low versus FAM214B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM214B→partner) and Y-score (partner→FAM214B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C-Raf →	+0.218	+2.841	.002	.033	3	3
UCEC	STAT5a →	+0.385	+1.906	.004	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.679	+1.434	<.001	.027	3	2
UCEC	14-3-3_beta →	-0.085	-1.308	.011	.030	3	1
UCEC	EGFR_pY1068 →	-0.192	-1.874	.022	.002	3	1
UCEC	EGFR →	-0.154	-1.906	.003	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

C-Raf by FAM214B expression — COAD

Explore this box plot interactively →