FAM214B

Across TCGA cell cohorts, FAM214B mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM214B-associated genes across cancer lineages are APOC4, PROP1, and NUPR2. Each is linked with FAM214B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM214B-to-partner and partner-to-FAM214B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APOC4 grouped by FAM214B-low versus FAM214B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM214B→partner) and Y-score (partner→FAM214B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	APOC4 →	+0.050	+5.266	<.001	.001	3	1
BLOOD_Leukemia	PROP1 →	+0.032	+4.874	<.001	.002	3	1
BLOOD_Leukemia	NUPR2 →	+0.065	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SPANXN1 →	+0.097	+4.152	<.001	.009	3	1
LARGE_INTESTINE	AVP →	+0.050	+3.632	<.001	<.001	3	1
LARGE_INTESTINE	PFN3 →	+0.090	+2.882	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

APOC4 by FAM214B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →