FAM20C

Across TCGA patient cohorts, FAM20C mutation is significantly associated with the RNA expression of many other genes, with 4,052 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM20C-associated genes across cancer lineages are FAM243A, MIR6799, and SPECC1L. Each is linked with FAM20C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM20C-to-partner and partner-to-FAM20C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM243A grouped by FAM20C-low versus FAM20C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM20C→partner) and Y-score (partner→FAM20C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM243A →	+0.009	+4.208	<.001	.003	3	2
BRCA	MIR6799 →	+0.357	+4.506	.001	.009	3	1
UCEC	SPECC1L →	+0.332	+3.807	.001	<.001	3	1
UCEC	MAPK1 →	+0.584	+2.069	<.001	<.001	3	1
UCEC	ESS2 →	+0.270	+1.788	.001	.001	3	1
UCEC	CRYBB2P1 →	+0.432	+2.566	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,052 associations by consensus.

FAM243A by FAM20C expression — UCEC

Explore this box plot interactively →