FAM20C

Across TCGA cell cohorts, FAM20C mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FAM20C-associated genes across cancer lineages are PROP1, SEMG2, and MSGN1. Each is linked with FAM20C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM20C-to-partner and partner-to-FAM20C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by FAM20C-low versus FAM20C-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM20C→partner) and Y-score (partner→FAM20C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PROP1 →	+0.023	+4.228	<.001	.006	3	2
LARGE_INTESTINE	SEMG2 →	+0.492	+3.878	.001	.003	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	S100G →	+1.372	+3.688	<.001	.002	3	1
LARGE_INTESTINE	GSC2 →	+0.116	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PROP1 by FAM20C expression — OVARY

Explore this box plot interactively →