FAM20B

Across TCGA patient cohorts, FAM20B mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM20B-associated genes across cancer lineages are ATM, Bak, and 14-3-3_beta. Each is linked with FAM20B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM20B-to-partner and partner-to-FAM20B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FAM20B-low versus FAM20B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM20B→partner) and Y-score (partner→FAM20B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.556	-2.446	.001	.018	3	2
UCEC	Bak →	+0.283	+3.584	.002	.002	3	2
UCEC	14-3-3_beta →	-0.103	-2.432	.006	.018	3	1
UCEC	EGFR_pY1068 →	-0.236	-2.000	.012	.029	3	1
UCEC	eIF4E →	+0.158	+2.183	.046	.033	3	1
UCEC	Fibronectin →	-0.246	-2.449	.047	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by FAM20B expression — UCEC

Explore this box plot interactively →