FAM20A

Across TCGA pan-cancer cohorts, FAM20A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM20A data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FAM20A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM20A expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where FAM20A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.988	0.511	.018	20	view →
PDAC	DFS	Tertile	All	0.246	0.586	.014	18	view →
HNSC	OS	Tertile	All	0.489	0.874	.007	12	view →
LUAD	OS	Tertile	All	0.891	1.000	.018	4	view →
GBM	DFS	Median	All	0.398	0.554	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM20A–LSCC (DFS)

Open the LSCC breakdown →