FAM20A

Across TCGA patient cohorts, FAM20A mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM20A-associated genes across cancer lineages are c-Met_pY1235, 14-3-3_beta, and EGFR_pY1068. Each is linked with FAM20A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM20A-to-partner and partner-to-FAM20A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by FAM20A-low versus FAM20A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM20A→partner) and Y-score (partner→FAM20A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.063	+1.906	.033	.016	3	2
UCEC	14-3-3_beta →	-0.099	-2.432	.013	.018	3	1
UCEC	EGFR_pY1068 →	-0.231	-1.906	.022	.016	3	1
UCEC	EGFR →	-0.215	-2.459	<.001	.019	3	1
UCEC	A-Raf_pS299 →	-0.112	-3.169	.020	.018	3	1
UCEC	FASN →	+0.449	+1.906	.004	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

c-Met_pY1235 by FAM20A expression — UCEC

Explore this box plot interactively →