FAM207A

Across TCGA patient cohorts, FAM207A mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM207A-associated genes across cancer lineages are Akt_pT308, EGFR_pY1068, and A-Raf_pS299. Each is linked with FAM207A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM207A-to-partner and partner-to-FAM207A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by FAM207A-low versus FAM207A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM207A→partner) and Y-score (partner→FAM207A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.541	+3.169	.049	.019	3	2
UCEC	EGFR_pY1068 →	-0.293	-3.906	.007	<.001	3	1
UCEC	A-Raf_pS299 →	-0.186	-3.321	<.001	.010	3	1
UCEC	INPP4B →	-0.397	-3.169	.004	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.102	.008	.019	3	1
UCEC	MEK1 →	+0.374	+2.807	.019	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Akt_pT308 by FAM207A expression — UCEC

Explore this box plot interactively →