Across TCGA patient cohorts, FAM205A mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM205A-associated genes across cancer lineages are EGFR_pY1068, Shc_pY317, and TFRC. Each is linked with FAM205A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM205A-to-partner and partner-to-FAM205A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM205A→partner) and Y-score (partner→FAM205A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.260	-3.459	.004	.005	3	2
UCEC	Shc_pY317 →	-0.158	-1.502	.004	.030	3	2
UCEC	TFRC →	+0.659	+2.736	<.001	<.001	3	2
UCEC	ATM →	-0.338	-2.308	.042	.033	3	2
COAD	Caspase-7-cleavedD198 →	+1.135	+2.815	.008	.036	3	2
UCEC	14-3-3_beta →	-0.089	-1.847	.015	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

FAM205A survival (RNA) · tumor vs normal (RNA) · all FAM205A data types