FAM189B

Across TCGA pan-cancer cohorts, FAM189B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM189B data layer compared with 27 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM189B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM189B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC and UCEC are the cancer types where FAM189B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.173	0.712	<.001	24	view →
UCEC	DFS	Median	All	1.000	0.830	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM189B–HNSC (DFS)

Open the HNSC breakdown →