FAM189B

Across TCGA patient cohorts, FAM189B mutation is significantly associated with the RNA expression of many other genes, with 1,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM189B-associated genes across cancer lineages are MRPL39, RN7SL66P, and RNA5SP419. Each is linked with FAM189B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM189B-to-partner and partner-to-FAM189B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL39 grouped by FAM189B-low versus FAM189B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189B→partner) and Y-score (partner→FAM189B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL39 →	+0.440	+2.425	.002	.002	3	2
CESC	RN7SL66P →	+0.192	+5.010	<.001	.009	3	2
UCEC	RNA5SP419 →	+0.606	+2.299	<.001	.001	3	2
UCEC	RNA5SP421 →	+0.669	+2.144	<.001	.002	3	2
UCEC	MYO19 →	+0.573	+3.724	<.001	<.001	3	2
LUSC	MIR449B →	+0.277	+7.924	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

MRPL39 by FAM189B expression — UCEC

Explore this box plot interactively →