FAM189B

Across TCGA patient cohorts, FAM189B mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM189B-associated genes across cancer lineages are Fibronectin, JNK2, and Ku80. Each is linked with FAM189B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM189B-to-partner and partner-to-FAM189B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by FAM189B-low versus FAM189B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189B→partner) and Y-score (partner→FAM189B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.359	-1.990	.012	.030	3	1
UCEC	JNK2 →	+0.248	+2.834	.004	.034	3	1
UCEC	Ku80 →	+0.241	+2.179	.019	.034	3	1
UCEC	Notch1 →	+0.146	+2.183	.017	.033	3	1
UCEC	Rab11 →	-0.148	-3.169	.019	.018	3	1
UCEC	Rad50 →	-0.267	-3.156	.011	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Fibronectin by FAM189B expression — UCEC

Explore this box plot interactively →