FAM189B

Across TCGA cell cohorts, FAM189B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,868 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FAM189B-associated GO terms across cancer lineages are IMP biosynthetic process, Aminoacyl-tRNA metabolism involved in translational fidelity, and Base-excision repair, gap-filling. Each is linked with FAM189B in more than 12 cancer types. Because this analysis shows association rather than direction, both FAM189B-to-partner and partner-to-FAM189B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP biosynthetic process grouped by FAM189B-low versus FAM189B-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189B→partner) and Y-score (partner→FAM189B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IMP biosynthetic process →	+0.195	+1.064	<.001	<.001	3	13
LARGE_INTESTINE	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.102	+0.845	<.001	<.001	3	13
LUNG_SCLC	Base-excision repair, gap-filling →	+0.113	+1.003	<.001	<.001	3	12
SKIN	Nucleoside triphosphate biosynthetic process →	+0.100	+0.704	<.001	<.001	3	12
SKIN	Ribonucleoside triphosphate biosynthetic process →	+0.093	+0.732	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of cation transmembrane transport →	-0.117	-0.677	.002	.004	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,868 associations by consensus.

IMP biosynthetic process by FAM189B expression — URINARY_TRACT

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