FAM189B

Across TCGA cell cohorts, FAM189B mutation is significantly associated with the RNA expression of many other genes, with 225 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FAM189B-associated genes across cancer lineages are USP17L15, LIPF, and DEFA3. Each is linked with FAM189B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM189B-to-partner and partner-to-FAM189B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L15 grouped by FAM189B-low versus FAM189B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189B→partner) and Y-score (partner→FAM189B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	USP17L15 →	+0.034	+3.635	<.001	.007	3	3
LUNG_NSCLC_LUSC	LIPF →	+0.046	+4.108	<.001	.005	3	2
SOFT_TISSUE	DEFA3 →	+0.123	+4.515	<.001	<.001	3	2
LARGE_INTESTINE	FOXE3 →	+0.173	+3.237	<.001	.008	3	2
BLOOD_Leukemia	IFNA4 →	+0.023	+2.922	<.001	.009	3	2
SKIN	RIT2 →	+0.017	+3.700	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 225 associations by consensus.

USP17L15 by FAM189B expression — SOFT_TISSUE

Explore this box plot interactively →