FAM189A2

Across TCGA patient cohorts, FAM189A2 mutation is significantly associated with the RNA expression of many other genes, with 1,694 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM189A2-associated genes across cancer lineages are DIMT1P1, OR5F2P, and AMY1C. Each is linked with FAM189A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM189A2-to-partner and partner-to-FAM189A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIMT1P1 grouped by FAM189A2-low versus FAM189A2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189A2→partner) and Y-score (partner→FAM189A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DIMT1P1 →	+0.030	+5.219	<.001	.002	3	3
SKCM	OR5F2P →	+0.025	+4.624	<.001	.005	3	2
SKCM	AMY1C →	+0.334	+5.485	<.001	.001	3	2
CESC	RNU6-912P →	+0.310	+4.010	<.001	.002	3	2
CESC	RPL17P49 →	+0.066	+4.342	<.001	.007	3	2
CESC	GAMTP2 →	+0.053	+4.342	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,694 associations by consensus.

DIMT1P1 by FAM189A2 expression — SKCM

Explore this box plot interactively →