FAM189A2

Across TCGA patient cohorts, FAM189A2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM189A2-associated genes across cancer lineages are ERK2, INPP4B, and MEK1_p_S217_S221. Each is linked with FAM189A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM189A2-to-partner and partner-to-FAM189A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FAM189A2-low versus FAM189A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189A2→partner) and Y-score (partner→FAM189A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.221	+2.000	.003	.010	3	2
UCEC	INPP4B →	-0.272	-3.321	.032	.009	3	2
UCEC	MEK1_p_S217_S221 →	-0.216	-2.459	.044	.019	3	2
UCEC	Notch1 →	+0.148	+1.594	.007	.042	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.447	-2.999	.011	.035	3	2
UCEC	TFRC →	+0.528	+3.169	.011	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ERK2 by FAM189A2 expression — UCEC

Explore this box plot interactively →