FAM189A1

Across TCGA patient cohorts, FAM189A1 mutation is significantly associated with the RNA expression of many other genes, with 238 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM189A1-associated genes across cancer lineages are MIR4633, NXPE2P1, and MIR5089. Each is linked with FAM189A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM189A1-to-partner and partner-to-FAM189A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4633 grouped by FAM189A1-low versus FAM189A1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189A1→partner) and Y-score (partner→FAM189A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4633 →	+0.697	+3.738	.002	.006	3	2
COAD	NXPE2P1 →	+0.375	+3.596	<.001	.004	3	2
COAD	MIR5089 →	+0.251	+4.251	.003	.008	3	2
LIHC	OR9I3P →	+0.029	+4.878	<.001	.005	3	1
LIHC	MIR6762 →	+0.485	+4.733	<.001	.003	3	1
BRCA	RNA5SP54 →	+0.229	+4.324	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 238 associations by consensus.

MIR4633 by FAM189A1 expression — BRCA

Explore this box plot interactively →