FAM189A1

Across TCGA patient cohorts, FAM189A1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM189A1-associated genes across cancer lineages are Lck, MSH6, and Annexin-1. Each is linked with FAM189A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM189A1-to-partner and partner-to-FAM189A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by FAM189A1-low versus FAM189A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189A1→partner) and Y-score (partner→FAM189A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.375	+2.999	<.001	.035	3	1
UCEC	MSH6 →	-0.632	-3.321	<.001	.010	3	1
UCEC	Annexin-1 →	+0.768	+3.019	.005	.019	3	1
UCEC	SF2 →	-0.175	-3.159	.002	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.998	+2.827	.001	.035	3	1
UCEC	MSH2 →	-0.514	-3.321	<.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Lck by FAM189A1 expression — UCEC

Explore this box plot interactively →