FAM189A1

Across TCGA cell cohorts, FAM189A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,627 significant associations in total. CNS shows the largest number of these associations.

The most reproducible FAM189A1-associated GO terms across cancer lineages are Dendritic spine maintenance, Negative regulation of myoblast fusion, and Interleukin-23-mediated signaling pathway. Each is linked with FAM189A1 in more than 5 cancer types. Because this analysis shows association rather than direction, both FAM189A1-to-partner and partner-to-FAM189A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dendritic spine maintenance grouped by FAM189A1-low versus FAM189A1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM189A1→partner) and Y-score (partner→FAM189A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Dendritic spine maintenance →	+0.099	+0.837	<.001	.002	3	5
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.066	+0.666	.001	.007	3	5
SKIN	Interleukin-23-mediated signaling pathway →	+0.089	+0.509	.004	.006	2	6
LUNG_SCLC	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.084	+0.847	<.001	.007	3	5
CNS	Alpha-beta T cell activation →	+0.053	+0.669	<.001	<.001	3	5
KIDNEY	Interleukin-7-mediated signaling pathway →	+0.210	+1.759	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,627 associations by consensus.

Dendritic spine maintenance by FAM189A1 expression — CNS

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