FAM183BP

Across TCGA patient cohorts, FAM183BP mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FAM183BP-associated genes across cancer lineages are STAT3_pY705, 4E-BP1, and FOXO3a_pS318_S321. Each is linked with FAM183BP in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM183BP-to-partner and partner-to-FAM183BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FAM183BP-low versus FAM183BP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM183BP→partner) and Y-score (partner→FAM183BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.341	-3.584	.004	.002	3	4
UCEC	4E-BP1 →	+0.427	+3.029	.002	.018	3	2
SKCM	FOXO3a_pS318_S321 →	+0.189	+1.749	.001	.049	3	1
SKCM	HER3 →	+0.436	+2.717	.018	.003	3	1
SKCM	Rab25 →	+0.282	+2.195	.012	.032	3	1
SKCM	Syk →	-0.580	-2.000	.008	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

STAT3_pY705 by FAM183BP expression — SKCM

Explore this box plot interactively →