Across TCGA cell cohorts, FAM180B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FAM180B-associated genes across cancer lineages are DMRTC2, OR6C2, and PRSS58. Each is linked with FAM180B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM180B-to-partner and partner-to-FAM180B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM180B→partner) and Y-score (partner→FAM180B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DMRTC2 →	+0.040	+5.415	.008	.004	3	1
SKIN	OR6C2 →	+0.015	+4.977	<.001	.007	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
SKIN	OPN1MW →	+0.032	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

FAM180B survival (RNA) · tumor vs normal (RNA) · all FAM180B data types