Across TCGA pan-cancer cohorts, FAM180A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FAM180A’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where FAM180A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM180A is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

PDAC, LUAD, and LSCC are the cancer types where FAM180A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM180A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+1.069	<.001	4	view →
LUAD	All	II,III,IV	−0.685	.008	1	view →
LSCC	Female	All	−0.483	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FAM180A RNA expression & survival · all FAM180A data types