Across TCGA pan-cancer cohorts, FAM174C Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM174C data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FAM174C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM174C expression acts as an unfavorable survival marker.

ACC and SKCM are the cancer types where FAM174C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
SKCM	DFS	Median	III,IV	0.088	0.613	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: FAM174C tumor-vs-normal RNA expression · all FAM174C data types