Across TCGA cell cohorts, FAM174C mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM174C-associated genes across cancer lineages are HIGD1C and SLC15A5. Each is linked with FAM174C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM174C-to-partner and partner-to-FAM174C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM174C→partner) and Y-score (partner→FAM174C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HIGD1C →	+0.102	+5.201	<.001	.006	3	1
LARGE_INTESTINE	SLC15A5 →	+0.023	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration

FAM174C survival (RNA) · tumor vs normal (RNA) · all FAM174C data types