Across TCGA cell cohorts, FAM174C mutation is significantly associated with the mutation status of many other genes, with 592 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM174C-associated genes across cancer lineages are THAP4, CD151, and LRRC41. Each is linked with FAM174C in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM174C-to-partner and partner-to-FAM174C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM174C→partner) and Y-score (partner→FAM174C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	THAP4 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	CD151 →	+5.321	+5.894	.002	.002	1	3
BLOOD_Leukemia	LRRC41 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	HHATL →	+5.321	+5.894	.002	.002	1	2
BLOOD_Leukemia	VAC14 →	+4.000	+5.050	.008	.008	1	2
BLOOD_Leukemia	CSPP1 →	+4.000	+5.050	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 592 associations by consensus.

Exploration

FAM174C survival (RNA) · tumor vs normal (RNA) · all FAM174C data types