Across TCGA pan-cancer cohorts, FAM174B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FAM174B data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM174B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM174B expression acts as an unfavorable survival marker.

HNSC, LUSC, and UCEC are the cancer types where FAM174B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.259	0.662	.007	36	view →
LUSC	OS	Median	All	0.086	0.776	<.001	36	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: FAM174B tumor-vs-normal RNA expression · all FAM174B data types