Across TCGA patient cohorts, FAM174B mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM174B-associated genes across cancer lineages are FoxM1, JNK2, and Notch1. Each is linked with FAM174B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM174B-to-partner and partner-to-FAM174B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM174B→partner) and Y-score (partner→FAM174B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.282	+2.000	.015	.032	3	1
UCEC	JNK2 →	+0.307	+3.807	<.001	<.001	3	1
UCEC	Notch1 →	+0.195	+2.700	.002	.006	3	1
UCEC	p62 Lck ligand →	+0.300	+2.700	.041	.006	3	1
UCEC	PDCD4 →	-0.444	-2.700	.036	.006	3	1
UCEC	Rictor_pT1135 →	-0.114	-2.000	.013	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

FAM174B survival (RNA) · tumor vs normal (RNA) · all FAM174B data types