FAM174A

Across TCGA pan-cancer cohorts, FAM174A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM174A data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FAM174A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM174A expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where FAM174A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.638	0.866	.005	23	view →
LUAD	DFS	Tertile	II,III,IV	0.663	1.000	.024	16	view →
CCRCC	DFS	Quartile	All	0.572	0.947	.009	5	view →
GBM	DFS	Median	All	0.545	0.251	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FAM174A–LSCC (DFS)

Open the LSCC breakdown →