FAM174A

Across TCGA cell cohorts, FAM174A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,504 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FAM174A-associated GO terms across cancer lineages are Regulation of endosome organization, Macroautophagy, and Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Each is linked with FAM174A in more than 12 cancer types. Because this analysis shows association rather than direction, both FAM174A-to-partner and partner-to-FAM174A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endosome organization grouped by FAM174A-low versus FAM174A-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM174A→partner) and Y-score (partner→FAM174A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of endosome organization →	+0.197	+1.032	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.072	+0.794	<.001	<.001	3	12
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.256	+1.656	<.001	<.001	3	12
BONE	Vacuole organization →	+0.054	+1.224	.002	.003	3	12
BONE	Membrane protein proteolysis →	+0.130	+1.224	.002	.001	2	13
BONE	Cotranslational protein targeting to membrane →	+0.098	+1.045	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,504 associations by consensus.

Regulation of endosome organization by FAM174A expression — URINARY_TRACT

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