FAM170A

Across TCGA patient cohorts, FAM170A mutation is significantly associated with the RNA expression of many other genes, with 787 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM170A-associated genes across cancer lineages are RNU4-14P, ASIC3, and MRPL37. Each is linked with FAM170A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM170A-to-partner and partner-to-FAM170A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-14P grouped by FAM170A-low versus FAM170A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM170A→partner) and Y-score (partner→FAM170A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU4-14P →	+0.277	+2.577	.005	.005	3	3
SKCM	ASIC3 →	+0.487	+1.913	<.001	<.001	3	3
SKCM	MRPL37 →	+0.298	+2.100	.003	.002	3	2
SKCM	PLEKHM2 →	+0.309	+1.301	.004	.006	3	2
SKCM	CLPP →	+0.252	+1.709	.006	.002	3	2
SKCM	DDA1 →	+0.206	+1.504	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 787 associations by consensus.

RNU4-14P by FAM170A expression — LUSC

Explore this box plot interactively →