FAM170A

Across TCGA patient cohorts, FAM170A mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM170A-associated genes across cancer lineages are Ku80, ATM, and JNK2. Each is linked with FAM170A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM170A-to-partner and partner-to-FAM170A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by FAM170A-low versus FAM170A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM170A→partner) and Y-score (partner→FAM170A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.264	+2.335	.026	.020	3	2
UCEC	ATM →	-0.582	-2.321	.010	.035	3	2
UCEC	JNK2 →	+0.269	+2.321	.007	.035	3	1
UCEC	Rad50 →	-0.251	-3.459	.039	.005	3	1
UCEC	Annexin-1 →	+0.557	+2.827	.035	.035	3	1
UCEC	XBP1 →	-0.205	-3.169	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Ku80 by FAM170A expression — UCEC

Explore this box plot interactively →