FAM168A

Across TCGA patient cohorts, FAM168A mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM168A-associated genes across cancer lineages are p62 Lck ligand, STAT3_pY705, and ATM. Each is linked with FAM168A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM168A-to-partner and partner-to-FAM168A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by FAM168A-low versus FAM168A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM168A→partner) and Y-score (partner→FAM168A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.435	+3.000	.020	.037	3	1
UCEC	STAT3_pY705 →	-0.532	-3.000	<.001	.037	3	1
UCEC	ATM →	-0.538	-3.000	.040	.037	3	1
UCEC	MSH2 →	-0.333	-3.000	.012	.037	2	1
UCEC	AR →	-0.677	-3.000	.001	.037	2	1
UCEC	Bak →	+0.379	+3.000	.008	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

p62 Lck ligand by FAM168A expression — UCEC

Explore this box plot interactively →