Across TCGA pan-cancer cohorts, FAM167B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM167B’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where FAM167B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM167B is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.
KICH, HNSC, and COAD are the cancer types where FAM167B tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM167B RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.