Across TCGA patient cohorts, FAM166A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM166A-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and eIF4G. Each is linked with FAM166A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM166A-to-partner and partner-to-FAM166A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM166A→partner) and Y-score (partner→FAM166A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.269	-3.459	.017	.005	3	2
UCEC	eIF4E →	+0.187	+2.820	.049	.035	3	1
UCEC	eIF4G →	+0.352	+3.169	.011	.019	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.000	.011	.032	3	1
UCEC	ERK2 →	+0.215	+2.459	.013	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.200	-2.687	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

FAM166A survival (RNA) · tumor vs normal (RNA) · all FAM166A data types