Across TCGA cell cohorts, FAM166A mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FAM166A-associated genes across cancer lineages are TBC1D21, GC, and GML. Each is linked with FAM166A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM166A-to-partner and partner-to-FAM166A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM166A→partner) and Y-score (partner→FAM166A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
SKIN	GC →	+0.046	+4.054	.005	.004	3	1
BLOOD_Leukemia	GML →	+0.078	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR56A4 →	+0.006	+4.874	.009	.002	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.010	+4.551	.001	.004	3	1
LUNG_NSCLC_LUAD	MS4A6E →	+0.044	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

FAM166A survival (RNA) · tumor vs normal (RNA) · all FAM166A data types