FAM163A

Across TCGA pan-cancer cohorts, FAM163A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FAM163A data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher FAM163A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM163A expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

UVM, KIRP, and KIRC are the cancer types where FAM163A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.411	0.808	<.001	113	view →
KIRP	DFS	Median	All	0.848	0.961	<.001	104	view →
KIRC	OS	Median	II,III,IV	0.767	0.622	<.001	70	view →
LIHC	DFS	Median	All	0.449	0.630	<.001	63	view →
MESO	OS	Tertile	All	0.292	0.539	.004	53	view →
PAAD	DFS	Quartile	All	0.619	0.355	.001	45	view →
BLCA	DFS	Median	II,III,IV	0.563	0.684	.007	33	view →
LGG	DFS	Tertile	All	0.880	0.754	<.001	31	view →
ACC	DFS	Tertile	II,III,IV	0.226	0.653	.017	26	view →
CHOL	DFS	Tertile	II,III,IV	0.674	0.083	.008	19	view →
READ	DFS	Tertile	III,IV	0.903	0.593	.016	17	view →
LUAD	DFS	Tertile	All	0.233	0.388	.003	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FAM163A–UVM (OS)

Open the UVM breakdown →