FAM161A

Across TCGA patient cohorts, FAM161A mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM161A-associated genes across cancer lineages are FASN, p27_pT198, and PCNA. Each is linked with FAM161A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM161A-to-partner and partner-to-FAM161A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by FAM161A-low versus FAM161A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM161A→partner) and Y-score (partner→FAM161A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.369	+2.736	.001	<.001	3	2
UCEC	p27_pT198 →	+0.077	+1.700	.017	.040	3	2
UCEC	PCNA →	+0.249	+2.070	<.001	.001	3	2
UCEC	Bak →	+0.175	+1.906	.020	.014	3	2
UCEC	Caspase-8 →	-0.260	-2.584	<.001	<.001	3	2
UCEC	C-Raf →	+0.184	+2.392	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FASN by FAM161A expression — UCEC

Explore this box plot interactively →