FAM157C

Across TCGA patient cohorts, FAM157C RNA expression is significantly associated with the protein abundance of many other proteins, with 10,397 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FAM157C-associated proteins across cancer lineages are ARHGEF12_T736, ARHGEF17_S1331, and RBX1. Each is linked with FAM157C in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM157C-to-partner and partner-to-FAM157C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FAM157C versus ARHGEF12_T736 in GBM, with a Pearson correlation of -0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM157C→partner) and Y-score (partner→FAM157C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGEF12_T736 →	-0.479	-0.266	<.001	<.001	3	3
PDAC	ARHGEF17_S1331 →	-0.585	-0.153	.001	.003	3	3
PDAC	RBX1 →	+0.170	+0.143	.008	.005	3	3
GBM	NFIA →	-0.427	-0.233	<.001	.001	3	3
LSCC	PDCD10 →	+0.213	+0.454	<.001	<.001	3	3
LSCC	ACAP2 →	+0.379	+0.386	.003	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,397 associations by consensus.

FAM157C vs ARHGEF12_T736 — GBM

Explore this scatter interactively →