FAM157B

Across TCGA patient cohorts, FAM157B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM157B-associated genes across cancer lineages are PDK1, PKC-a, and 14-3-3_zeta. Each is linked with FAM157B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM157B-to-partner and partner-to-FAM157B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1 grouped by FAM157B-low versus FAM157B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM157B→partner) and Y-score (partner→FAM157B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1 →	-0.127	-3.321	.024	.010	3	1
UCEC	PKC-a →	+0.441	+3.013	.038	.018	3	1
UCEC	14-3-3_zeta →	-0.259	-3.295	.016	.010	3	1
UCEC	JNK2 →	+0.315	+3.321	.002	.010	2	1
UCEC	Mre11 →	-0.156	-3.321	<.001	.010	2	1
UCEC	Di-Ras3 →	-0.208	-3.000	.007	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PDK1 by FAM157B expression — UCEC

Explore this box plot interactively →