Across TCGA pan-cancer cohorts, FAM155A-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM155A-IT1’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where FAM155A-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM155A-IT1 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
STAD, CHOL, and BRCA are the cancer types where FAM155A-IT1 tumor–normal differential expression is most reproducible.