FAM153B

Across TCGA pan-cancer cohorts, FAM153B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM153B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FAM153B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM153B is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

LUAD, UCEC, and KIRP are the cancer types where FAM153B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM153B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.251	<.001	8	view →
UCEC	All	All	−0.950	<.001	6	view →
KIRP	All	All	−0.345	<.001	6	view →
BRCA	All	III,IV	−0.055	<.001	6	view →
THCA	All	All	+0.241	.001	5	view →
LUSC	Male	III,IV	−0.400	<.001	3	view →
BLCA	All	III,IV	−0.034	.028	2	view →
COAD	All	All	−0.013	.007	2	view →
CHOL	All	All	+0.557	.018	1	view →
KIRC	Male	All	−0.145	.045	1	view →
ESCA	Female	All	−0.123	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FAM153B–LUAD

Open the LUAD breakdown →